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Article

Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity.

The Journal of biological chemistry - 19 Nov 2004

Campopiano Dominic J, Clarke David J, Polfer Nick C, Barran Perdita E, Langley Ross J, Govan John R W, Maxwell Alison, Dorin Julia R

Abstract excerpt

Defensins are cationic antimicrobial peptides that have a characteristic six-cysteine motif and are important components of the innate immune system. We recently described a beta-defensin-related peptide (Defr1) that had potent antimicrobial activity despite having only five cysteines. Here we report a relationship between the structure and activity of Defr1 through a comparative study with its six...

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PMID: 15317821
DOI: 10.1074/jbc.M404690200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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