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Article

Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites.

Journal of virology - 1 Mar 2013

Wang Aiping, Chen Fang, Wang Yingjie, Shen Mingqiang, Xu Yang, Hu Jian, Wang Song, Geng Fang, Wang Cheng, Ran Xinze, Su Yongping, Cheng Tianmin, Wang Junping

Abstract excerpt

Herpes simplex virus 2 (HSV-2) infection is still one of the common causes of sexually transmitted diseases worldwide. The prevalence of HSV strains resistant to traditional nucleoside antiviral agents has led to the development of novel antiviral drugs. Human alpha-defensin 5 (HD5), a kind of endogenous antimicrobial peptide expressed in the epithelia of the small intestine and urogenital tract, displays natural...

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Identifiers

PMID: 23269800
DOI: 10.1128/JVI.02209-12
PMCID: PMC3571410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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