Article
Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4.
The Journal of biological chemistry - 22 Sept 2006
Rosengren K Johan, Daly Norelle L, Fornander Liselotte M, Jönsson Linda M H, Shirafuji Yoshinori, Qu Xiaoqing, Vogel Hans J, Ouellette Andre J, Craik David J
Abstract excerpt
alpha-Defensins are mediators of mammalian innate immunity, and knowledge of their structure-function relationships is essential for understanding their mechanisms of action. We report here the NMR solution structures of the mouse Paneth cell alpha-defensin cryptdin-4 (Crp4) and a mutant (E15D)-Crp4 peptide, in which a conserved Glu(15) residue was replaced by Asp. Structural analysis of the two peptides confirms...
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