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Article

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance.

Amino acids - 1 Oct 2012

Andersson Håkan S, Figueredo Sharel M, Haugaard-Kedström Linda M, Bengtsson Elina, Daly Norelle L, Qu Xiaoqing, Craik David J, Ouellette André J, Rosengren K Johan

Abstract excerpt

Salt-bridge interactions between acidic and basic amino acids contribute to the structural stability of proteins and to protein-protein interactions. A conserved salt-bridge is a canonical feature of the α-defensin antimicrobial peptide family, but the role of this common structural element has not been fully elucidated. We have investigated mouse Paneth cell α-defensincryptdin-4 (Crp4) and peptide variants with...

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Identifiers

PMID: 22286872
DOI: 10.1007/s00726-012-1220-3
PMCID: PMC4086743

Genes

MMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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