Expression and structure/function relationships of human defensin 5.

doi:10.1007/s12010-012-9571-5

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Article

Expression and structure/function relationships of human defensin 5.

Applied biochemistry and biotechnology - 1 Apr 2012

Chapnik Nava, Levit Anat, Niv Masha Y, Froy Oren

Abstract excerpt

The innate immunity utilizes a battery of broad-spectrum antibacterial cationic polypeptides (3-5 kDa), among them defensins. In humans, defensins are the first line of defense against pathogens and their expression has been implicated in several diseases. The antibacterial activity of defensins is generally ascribed to their overall positive charge, which enables them to disrupt bacterial membrane integrity and...

Topics

Amino Acid Sequence
Anti-Bacterial Agents
Arginine
Chromatography, High Pressure Liquid
Cloning, Molecular
Escherichia coli
Gene Expression
Humans
Microbial Viability
Models, Molecular
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Mutation

Plasmids

Recombinant Proteins

Static Electricity

Structure-Activity Relationship

alpha-Defensins

Source

Open in PubMed

Identifiers

PMID: 22354633
DOI: 10.1007/s12010-012-9571-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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