Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study.

BMC medical genetics - 22 May 2008

Laramie Jason M, Wilk Jemma B, Williamson Sally L, Nagle Michael W, Latourelle Jeanne C, Tobin Jennifer E, Province Michael A, Borecki Ingrid B, Myers Richard H

Abstract excerpt

BACKGROUND: The chromosome 7q32 region is linked to metabolic syndrome and obesity related traits in the Family Heart Study. As part of a fine mapping study of the region, we evaluated the relationship of polymorphisms to fasting glucose levels and Type 2 diabetes. METHODS: Thirty-nine HapMap defined tag SNPs in a 1.08 Mb region and a novel deletion polymorphism were genotyped in 2,603 participants of the NHLBI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Chromosomes, Human, Pair 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Family

Share to Heart Diseases

Share to Metabolic Syndrome

Share to Sequence Deletion

Share to United States

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18498660
DOI: 10.1186/1471-2350-9-46
PMCID: PMC2409301

Genes

EXOC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study.PMID 18498660Read ↗

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.Semantic proximity Read ↗

A comprehensive reanalysis of publicly available GWAS datasets reveals an X chromosome rare regulatory variant associated with high risk for type 2 diabetesSemantic proximity Read ↗

Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.Semantic proximity Read ↗

Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.Semantic proximity Read ↗

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.Semantic proximity Read ↗

Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.Semantic proximity Read ↗

A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women.Semantic proximity Read ↗

The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis.Semantic proximity Read ↗

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.Semantic proximity Read ↗

Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans.Semantic proximity Read ↗

Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.Semantic proximity Read ↗

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.