Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.

doi:10.1038/ng1732

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Article

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.

Nature genetics - 1 Mar 2006

Grant Struan F A, Thorleifsson Gudmar, Reynisdottir Inga, Benediktsson Rafn, Manolescu Andrei, Sainz Jesus, Helgason Agnar, Stefansson Hreinn, Emilsson Valur, Helgadottir Anna, Styrkarsdottir Unnur, Magnusson Kristinn P, Walters G Bragi, Palsdottir Ebba, Jonsdottir Thorbjorg, Gudmundsdottir Thorunn, Gylfason Arnaldur, Saemundsdottir Jona, Wilensky Robert L, Reilly Muredach P, Rader Daniel J, Bagger Yu, Christiansen Claus, Gudnason Vilmundur, Sigurdsson Gunnar, Thorsteinsdottir Unnur, Gulcher Jeffrey R, Kong Augustine, Stefansson Kari

Abstract excerpt

We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 x 10(-9)). This was replicated...

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PMID: 16415884
DOI: 10.1038/ng1732

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TCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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