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Article

Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.

Diabetes - 1 Oct 2007

Sale Michèle M, Smith Shelly G, Mychaleckyj Josyf C, Keene Keith L, Langefeld Carl D, Leak Tennille S, Hicks Pamela J, Bowden Donald W, Rich Stephen S, Freedman Barry I

Abstract excerpt

OBJECTIVE: Recently, variants in the TCF7L2 gene have been reported to be associated with type 2 diabetes across multiple Europid populations, but only one small sample of African-American type 2 diabetic patients has been examined. Our objective was to investigate the importance of TCF7L2 in a l...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17601994
DOI: 10.2337/db07-0012

Genes

CAPN10
KCNJ11
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17601994-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.PMID 17601994Read ↗

Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.Semantic proximity Read ↗

Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study.Semantic proximity Read ↗

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Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.Semantic proximity Read ↗

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.Semantic proximity Read ↗

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.Semantic proximity Read ↗

Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.Semantic proximity Read ↗

Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.Semantic proximity Read ↗

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Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.Semantic proximity Read ↗

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