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Article

Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans.

Diabetes - 1 Feb 2007

Lehman Donna M, Hunt Kelly J, Leach Robin J, Hamlington Jeanette, Arya Rector, Abboud Hanna E, Duggirala Ravindranath, Blangero John, Göring Harald H H, Stern Michael P

Abstract excerpt

TCF7L2 acts as both a repressor and transactivator of genes, as directed by the Wnt signaling pathway. Recently, several highly correlated sequence variants located within a haplotype block of the TCF7L2 gene were observed to associate with type 2 diabetes in three Caucasian cohorts. We previousl...

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Identifiers

PMID: 17259383
DOI: 10.2337/db06-0860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17259383-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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