Article
Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
Diabetes - 1 Sept 2006
Damcott Coleen M, Pollin Toni I, Reinhart Laurie J, Ott Sandra H, Shen Haiqing, Silver Kristi D, Mitchell Braxton D, Shuldiner Alan R
Abstract excerpt
Transcription factor 7-like 2 (TCF7L2) regulates genes involved in cell proliferation and differentiation. The TCF7L2 gene is located on chromosome 10q25 in a region of replicated linkage to type 2 diabetes. Recently, a microsatellite marker in intron 3 (DG10S478) and five correlated single nucleotide polymorphisms (SNPs) were identified in Icelandic individuals that showed strong association with type 2...
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