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Article

Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia.

International journal of oncology - 1 Jun 2008

Chen Po-Min, Yen Chueh-Chuan, Wang Wei-Shu, Lin Yu-Jen, Chu Chiau-Jun, Chiou Tzeon-Jye, Liu Jin-Hwang, Yang Muh-Hwa

Abstract excerpt

The Notch receptor-mediated signaling pathways control cell fate in many types of organisms including neurogenesis, myogenesis and hematopoiesis in mammalian species. During normal hematopoiesis, Notch-1 promotes myeloid differentiation through up-regulation of the transcriptional factor PU.1. We therefore speculated that down-regulation of Notch-1 expression might be involved in the leukemogenesis of acute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Polymorphism, Single-Stranded Conformational

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Share to Receptor, Notch1

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Source

Identifiers

PMID: 18497996
DOI: 10.3892/ijo_32_6_1335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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