Article
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.
Blood - 9 Oct 2014
Staber Philipp B, Zhang Pu, Ye Min, Welner Robert S, Levantini Elena, Di Ruscio Annalisa, Ebralidze Alexander K, Bach Christian, Zhang Hong, Zhang Junyan, Vanura Katrina, Delwel Ruud, Yang Henry, Huang Gang, Tenen Daniel G
Abstract excerpt
Runx transcription factors contribute to hematopoiesis and are frequently implicated in hematologic malignancies. All three Runx isoforms are expressed at the earliest stages of hematopoiesis; however, their function in hematopoietic stem cells (HSCs) is not fully elucidated. Here, we show that Runx factors are essential in HSCs by driving the expression of the hematopoietic transcription factor PU.1....
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