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Article

miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias.

Leukemia research - 1 Feb 2015

Riccioni Roberta, Lulli Valentina, Castelli Germana, Biffoni Mauro, Tiberio Rosella, Pelosi Elvira, Lo-Coco Francesco, Testa Ugo

Abstract excerpt

MicroRNAs (miRs) play a key role in the pathogenesis of human malignancies and particularly in acute myeloid leukemias (AMLs) and are increasingly recognized as potential biomarkers and therapeutic targets. miR-21 is dysregulated in several types of cancers, including some hematologic malignancies, and plays a key role in carcinogenesis, disease recurrence and metastasis. However, no studies have specifically...

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Source

Identifiers

PMID: 25543261
DOI: 10.1016/j.leukres.2014.11.001

Genes

PDCD4
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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