Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias.

Leukemia research - 1 Feb 2015

Riccioni Roberta, Lulli Valentina, Castelli Germana, Biffoni Mauro, Tiberio Rosella, Pelosi Elvira, Lo-Coco Francesco, Testa Ugo

Abstract excerpt

MicroRNAs (miRs) play a key role in the pathogenesis of human malignancies and particularly in acute myeloid leukemias (AMLs) and are increasingly recognized as potential biomarkers and therapeutic targets. miR-21 is dysregulated in several types of cancers, including some hematologic malignancie...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Gene Expression Regulation, Leukemic
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Neoplasm Proteins

Share to Nucleophosmin

Share to RNA-Binding Proteins

Share to RNA, Neoplasm

Source

Identifiers

PMID: 25543261
DOI: 10.1016/j.leukres.2014.11.001

Genes

PDCD4
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25543261-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias.PMID 25543261Read ↗

Biological and clinical consequences of NPM1 mutations in AML.Semantic proximity Read ↗

The pathological role and prognostic impact of miR-181 in acute myeloid leukemiaSemantic proximity Read ↗

Prognostic Significance of miR-181a and miR-181b Expression and NPM1 Mutations in Patients With Acute Myeloid Leukemia Undergoing Hematopoietic Stem Cell Transplant.Semantic proximity Read ↗

Mutant NPM1 maintains RASGRP3 protein stability via interaction with MID1 to promote acute myeloid leukemia cell proliferation and autophagy.Semantic proximity Read ↗

Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines.Semantic proximity Read ↗

PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia.Semantic proximity Read ↗

PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathwaySemantic proximity Read ↗

Increased expression of miR-24 is associated with acute myeloid leukemia with t(8;21).Semantic proximity Read ↗

MiR-10a-5p regulates proliferation, apoptosis and cell cycle of NPM1-mutated acute myeloid leukemia cells by targeting SHANK3Semantic proximity Read ↗

miR-15a-5p and miR-21-5p contribute to chemoresistance in cytogenetically normal acute myeloid leukaemia by targeting PDCD4, ARL2 and BTG2.Semantic proximity Read ↗

Upregulation of microRNA-21 is a poor prognostic marker in patients with childhood B cell acute lymphoblastic leukemiaSemantic proximity Read ↗

The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.