Article
Notch activation inhibits AML growth and survival: a potential therapeutic approach.
The Journal of experimental medicine - 11 Feb 2013
Kannan Sankaranarayanan, Sutphin Robert M, Hall Mandy G, Golfman Leonard S, Fang Wendy, Nolo Riitta M, Akers Lauren J, Hammitt Richard A, McMurray John S, Kornblau Steven M, Melnick Ari M, Figueroa Maria E, Zweidler-McKay Patrick A
Abstract excerpt
Although aberrant Notch activation contributes to leukemogenesis in T cells, its role in acute myelogenous leukemia (AML) remains unclear. Here, we report that human AML samples have robust expression of Notch receptors; however, Notch receptor activation and expression of downstream Notch targets are remarkably low, suggesting that Notch is present but not constitutively activated in human AML. The functional...
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