Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

16 Dec 2002

Abstract excerpt

The transcription factor PU.1 plays a pivotal role in normal myeloid differentiation. PU.1(-/-) mice exhibit a complete block in myeloid differentiation. Heterozygous PU.1 mutations were reported in some patients with acute myeloid leukemia (AML), but not in AML with translocation t(8;21), which gives rise to the fusion gene AML1-ETO. Here we report a negative functional impact of AML1-ETO on the transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Myeloid Leukemia Treatments
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12393465
DOI: 10.1182/blood-2002-04-1288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemiaPMID 12393465Read ↗

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Semantic proximity Read ↗

Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoterSemantic proximity Read ↗

PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element.Semantic proximity Read ↗

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced deathSemantic proximity Read ↗

An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells.Semantic proximity Read ↗

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Semantic proximity Read ↗

RUNX1-ETO: Attacking the Epigenome for Genomic Instable LeukemiaSemantic proximity Read ↗

C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia.Semantic proximity Read ↗

Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.Semantic proximity Read ↗

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.Semantic proximity Read ↗

The AML1/ETO fusion protein activates transcription of BCL-2Semantic proximity Read ↗

The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional ActivationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.