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Article

The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy.

Seizure - 1 Sept 2008

Basic Silvio, Hajnsek Sanja, Bozina Nada, Filipcic Igor, Sporis Davor, Mislov Damir, Posavec Ana

Abstract excerpt

BACKGROUND: Epilepsy is refractory to medical treatment in about one-third of the patients. The exact pathological mechanism of epilepsy pharmacoresistance is still unclear, but a decreased antiepileptic drug (AED) uptake into the brain is suspected to play a role. P-glycoprotein (Pgp), a transme...

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Source

Identifiers

PMID: 18329296
DOI: 10.1016/j.seizure.2008.01.003

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18329296-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy.PMID 18329296Read ↗

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ABCB1 gene C3435T polymorphism and drug resistance in epilepsy: evidence based on 8,604 subjects.Semantic proximity Read ↗

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The ABCB1-C3435T polymorphism likely acts as a risk factor for resistance to antiepileptic drugs.Semantic proximity Read ↗

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