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Article

Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese.

Epilepsy & behavior : E&B - 1 Aug 2007

Kwan Patrick, Baum Larry, Wong Virginia, Ng Ping Wing, Lui Colin Ht, Sin Ngai Chuen, Hui Andrew C F, Yu Evelyn, Wong Lawrence K S

Abstract excerpt

There is accumulating evidence to suggest that overexpression of efflux drug transporters at the blood-brain barrier, by reducing antiepileptic drug (AED) accumulation in the seizure foci, contributes to drug resistance in epilepsy. P-glycoprotein, encoded by the ABCB1 gene, is the most studied drug transporter. There are conflicting data as to whether the CC genotype of the ABCB1 3435C>T polymorphism is...

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Identifiers

PMID: 17521963
DOI: 10.1016/j.yebeh.2007.04.013

Genes

ABCB1

Variants

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