Article
Breaking the immunosuppressive barrier: an armored CAR-M biotechnology with the original M1 phenotype dominance rescues antitumor immunity.
Trends in biotechnology - 1 Jul 2026
Du Fuyu, Xu Yuanhui, Chu Wenhui, Qiu Jingjing, Jiang Meixi, Wang Xinruo, Guan Dashan, Su Maozhi, He Anna, Ye Zixuan, Xia Yuqiong, Zhang Xianghan, Wang Zhongliang, Ning Pengbo
Abstract excerpt
Chimeric antigen receptor macrophages (CAR-Ms) hold promise for solid tumor immunotherapy, but their efficacy is limited by tumor microenvironment (TME)-driven M2 polarization. Current strategies rely on antigen-dependent activation or in vitro priming, which fail to sustain the M1 phenotype in the immunosuppressive TME. In this research article, we developed a TME-regulated CAR-M (TMER CAR-M) biotechnology by...
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