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Article

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages.

Oncotarget - 31 Jan 2017

Takahashi Hideyuki, Sakakura Koichi, Kudo Takeshi, Toyoda Minoru, Kaira Kyoichi, Oyama Tetsunari, Chikamatsu Kazuaki

Abstract excerpt

Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by which cancer-associated fibroblasts (CAFs) affect the functional polarization of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC) in vitro and in human cancer samples. The expression of CD68, CD14, CD163, CD200R,...

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Source

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Identifiers

PMID: 28052009
DOI: 10.18632/oncotarget.14374
PMCID: PMC5352428

Genes

ARG1
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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