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Article

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages.

Oncotarget - 31 Jan 2017

Takahashi Hideyuki, Sakakura Koichi, Kudo Takeshi, Toyoda Minoru, Kaira Kyoichi, Oyama Tetsunari, Chikamatsu Kazuaki

Abstract excerpt

Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by which cancer-associated fibroblasts (CAFs) affect the functional polarization of tumor-associated macrophages (TAMs) in o...

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Source

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Identifiers

PMID: 28052009
DOI: 10.18632/oncotarget.14374
PMCID: PMC5352428

Genes

ARG1
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-28052009-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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