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Article

Tumour-associated macrophage polarisation and re-education with immunotherapy.

Frontiers in bioscience (Elite edition) - 1 Jan 2015

Josephs Debra H, Bax Heather J, Karagiannis Sophia N

Abstract excerpt

Monocytes/macrophages constitute important contributors of cancer-associated inflammation. Through their plasticity and capacity to become polarised by tumours towards less activatory and more immunosuppressive (M2) phenotypes, tumour-associated macrophages (TAM) are thought to support tumour progression. Orchestrated by T helper 2 (Th2)-biased stimuli, macrophage recruitment, activation and polarisation in...

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PMID: 25553381
DOI: 10.2741/E735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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