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Article

Polymorphism of FGFR4 in cancer development and sensitivity to cisplatin and radiation in head and neck cancer.

Oral oncology - 1 Jan 2009

Ansell Anna, Farnebo Lovisa, Grénman Reidar, Roberg Karin, Thunell Lena K

Abstract excerpt

The aim of this study was to investigate the predisposition of the FGFR4 Gly/Arg polymorphism for development of head and neck squamous cell carcinoma (HNSCC) and, furthermore, to examine if the FGFR4 Arg(388) allele can be associated with resistance to chemo- and radiotherapy. When analysing 110 tumour biopsies a significant 1.7-fold increased risk to develop HNSCC in individuals carrying the Gly(388) allele...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Cisplatin

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Share to Receptor, Fibroblast Growth Factor, Type 4

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Source

Identifiers

PMID: 18487077
DOI: 10.1016/j.oraloncology.2008.03.007

Genes

FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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