Article
Low dose IL-15 induces snap arming of CD44(low) T lymphocytes in the absence of antigen.
Cellular immunology - 1 Feb 2008
Tamang David L, Alves Bryce N, Elliott Viki, Fraser Stephanie A, Redelman Doug, Hudig Dorothy
Abstract excerpt
It is widely accepted that naïve T cells require two signals, antigen recognition and co-simulation, to become cytotoxic over the course of 3-5days. However, we observed that freshly isolated murine splenocytes without exposure to antigen become cytotoxic within 24h after culture with IL-15. IL-15 is a cytokine that promotes homeostatic proliferation, maintenance and activation of memory T cells. The induced...
Topics
- Animals
- Antigens
- CD8-Positive T-Lymphocytes
- Cell Growth Processes
- Cytotoxicity Tests, Immunologic
- Granzymes
- Hyaluronan Receptors
- Immunologic Memory
- Interleukin-15
- Lymphocyte Activation
- Mice