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Article

Implication of Interleukin-12/15/18 and Ruxolitinib in the Phenotype, Proliferation, and Polyfunctionality of Human Cytokine-Preactivated Natural Killer Cells.

Frontiers in immunology - 1 Jan 2018

Terrén Iñigo, Mikelez Idoia, Odriozola Irati, Gredilla Andrea, González Javier, Orrantia Ane, Vitallé Joana, Zenarruzabeitia Olatz, Borrego Francisco

Abstract excerpt

A brief in vitro stimulation of natural killer (NK) cells with interleukin (IL)-12, IL-15, and IL-18 endow them a memory-like behavior, characterized by higher effector responses when they are restimulated after a resting period of time. These preactivated NK cells, also known as cytokine-induced memory-like (CIML) NK cells, have several properties that make them a promising tool in cancer immunotherapy. In the...

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Identifiers

PMID: 29713323
DOI: 10.3389/fimmu.2018.00737
PMCID: PMC5911648

Genes

CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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