Article

TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8 <sup>+</sup> T cells

2025-01-15

Abstract excerpt

<h4>Summary</h4> Here we investigated the regulatory mechanisms of TCR-independent bystander activation and NK-like cytotoxicity of human memory CD8 + T cells. We found that TCR signals suppressed characteristic features of IL-15-induced CD8 + T-cell activation, including increased NKG2D expression and upregulation of genes related to NK cytotoxicity and IFN response. Moreover, ionomycin suppressed IL-15-induce...

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Literature Corpus work: eb99115f-39f7-5175-91d8-3da8faa351cd
DOI: 10.1101/2025.01.13.632884

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