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Article

Antiviral CD4+ memory T cells are IL-15 dependent.

The Journal of experimental medicine - 16 Apr 2007

Purton Jared F, Tan Joyce T, Rubinstein Mark P, Kim David M, Sprent Jonathan, Surh Charles D

Abstract excerpt

Survival and intermittent proliferation of memory CD4(+) and CD8(+) T cells appear to be controlled by different homeostatic mechanisms. In particular, contact with interleukin (IL)-15 has a decisive influence on memory CD8(+) cells, but not memory CD4(+) cells. Past studies of memory CD4(+) cells have relied heavily on the use of naturally occurring memory phenotype (MP) cells as a surrogate for antigen...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17420265
DOI: 10.1084/jem.20061805
PMCID: PMC2118539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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