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Article

Human liver CD8+ MAIT cells exert TCR/MR1-independent innate-like cytotoxicity in response to IL-15.

Journal of hepatology - 1 Sept 2020

Rha Min-Seok, Han Ji Won, Kim Jong Hoon, Koh June-Young, Park Hye Jung, Kim Soon Il, Kim Myoung Soo, Lee Jae Geun, Lee Hyun Woong, Lee Dong Hyeon, Kim Won, Park Jun Yong, Joo Dong Jin, Park Su-Hyung, Shin Eui-Cheol

Abstract excerpt

BACKGROUND & AIMS: Mucosal-associated invariant T (MAIT) cells, the most abundant innate-like T cells in the human liver, can be activated by cytokines during viral infection without TCR stimulation. Here, we examined the mechanisms underlying TCR/MR1-independent innate-like cytotoxicity of cytokine-activated liver MAIT cells. We also examined the phenotype and function of MAIT cells from patients with acute...

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Identifiers

PMID: 32247824
DOI: 10.1016/j.jhep.2020.03.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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