Turnover of memory-phenotype CD8+ T cells.

doi:10.1016/s1286-4579(03)00015-7

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Article

Turnover of memory-phenotype CD8+ T cells.

Microbes and infection - 1 Mar 2003

Sprent Jonathan

Abstract excerpt

Memory-phenotype (CD44(hi)) T cells are presumed to represent the long-lived progeny of T cells responding to various environmental antigens. For CD8+ T cells, the background rate of proliferation (turnover) of memory-phenotype cells is increased following exposure to infectious agents. This increase in turnover is controlled by interferons (IFN-I and IFN-gamma) and is mediated by IL-15. Unlike IFNs, IL-15 is...

Topics

Animals
CD8-Positive T-Lymphocytes
Humans
Immunologic Memory
Interferons
Interleukin-15
Lymphocyte Activation
Mice
Phenotype
T-Lymphocyte Subsets

Source

Open in PubMed

Identifiers

PMID: 12681412
DOI: 10.1016/s1286-4579(03)00015-7

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