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Article

IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18.

Cancer immunology, immunotherapy : CII - 1 Sept 2020

Oka Naoto, Markova Tzvetanka, Tsuzuki Kenzo, Li Wen, El-Darawish Yosif, Pencheva-Demireva Magdalena, Yamanishi Kyousuke, Yamanishi Hiromichi, Sakagami Masafumi, Tanaka Yoshimasa, Okamura Haruki

Abstract excerpt

NK cells, which are composed of phenotypically and functionally heterogeneous subpopulations, play critical roles in immunity against cancer. The mechanism of generation of distinct subsets such as the effector and regulatory subtypes is unclear. Here, we show that this process comprises several steps, including generation of proliferating, highly cytotoxic cells activated by IL-15/IL-18 and differentiation into...

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Identifiers

PMID: 32333080
DOI: 10.1007/s00262-020-02553-4
PMCID: PMC11027610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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