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Article

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Liu Kebin, Catalfamo Marta, Li Yu, Henkart Pierre A, Weng Nan-ping

Abstract excerpt

Generation of CD8(+) memory T cells requires antigenic stimulation through T cell receptor (TCR); however, maintenance of CD8(+) memory T cells seems to be mediated by cytokines, such as IL-15, in a TCR-independent manner. Compared with the TCR-induced activation, less is known about the mechanisms of IL-15 action. We report here a comparative and kinetic analysis of the responses of memory phenotype CD8(+) T...

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Identifiers

PMID: 11972069
DOI: 10.1073/pnas.092675799
PMCID: PMC122925

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