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Article

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.

The Journal of experimental medicine - 6 Aug 2007

Cho Jae-Ho, Boyman Onur, Kim Hee-Ok, Hahm Bumsuk, Rubinstein Mark P, Ramsey Chris, Kim David M, Surh Charles D, Sprent Jonathan

Abstract excerpt

In conditions of T lymphopenia, interleukin (IL) 7 levels rise and, via T cell receptor for antigen-self-major histocompatibility complex (MHC) interaction, induce residual naive T cells to proliferate. This pattern of lymphopenia-induced "homeostatic" proliferation is typically quite slow and causes a gradual increase in total T cell numbers and differentiation into cells with features of memory cells. In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17664294
DOI: 10.1084/jem.20070740
PMCID: PMC2118670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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