Article
Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities.
Genesis (New York, N.Y. : 2000) - 1 Nov 2021
Palmer Alexandra J, Savery Dawn, Massa Valentina, Copp Andrew J, Greene Nicholas D E
Abstract excerpt
Mouse models provide opportunities to investigate genetic interactions that cause or modify the frequency of neural tube defects (NTDs). Mutation of the PAX3 transcription factor prevents neural tube closure, leading to cranial and spinal NTDs whose frequency is responsive to folate status. Canonical Wnt signalling is implicated both in regulation of Pax3 expression and as a target of PAX3. This study...
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