Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The expression and function of PAX3 in development and disease.

Gene - 5 Aug 2018

Boudjadi Salah, Chatterjee Bishwanath, Sun Wenyue, Vemu Prasantha, Barr Frederic G

Abstract excerpt

The PAX3 gene encodes a member of the PAX family of transcription factors that is characterized by a highly conserved paired box motif. The PAX3 protein is a transcription factor consisting of an N-terminal DNA binding domain (containing a paired box and homeodomain) and a C-terminal transcriptional activation domain. This protein is expressed during development of skeletal muscle, central nervous system and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression
Share to Gene Expression Regulation, Developmental
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to PAX3 gene

Share to Mutation

Share to PAX3 Transcription Factor

Share to Sarcoma

Share to Waardenburg Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 29730428
DOI: 10.1016/j.gene.2018.04.087
PMCID: PMC6624083

Genes

PAX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The expression and function of PAX3 in development and disease.PMID 29730428Read ↗

<i>Pax</i> genes in embryogenesis and oncogenesisSemantic proximity Read ↗

Pax: gene regulators in the developing nervous system.Semantic proximity Read ↗

Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I).Semantic proximity Read ↗

Identification of two PAX3 mutations causing Waardenburg syndrome, one within the paired domain (M62V) and the other downstream of the homeodomain (Q282X).Semantic proximity Read ↗

Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice.Semantic proximity Read ↗

PAX3 gene structure and mutations: close analogies between Waardenburg syndrome and the Splotch mouse.Semantic proximity Read ↗

PAX genes.Semantic proximity Read ↗

Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease.Semantic proximity Read ↗

Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives.Semantic proximity Read ↗

Pax and vertebrate development.Semantic proximity Read ↗

Genomic organization of the human PAX3 gene: DNA sequence analysis of the region disrupted in alveolar rhabdomyosarcoma.Semantic proximity Read ↗

A splice-site mutation affecting the paired box of PAX3 in a three generation family with Waardenburg syndrome type I (WS1).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.