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Article

Impaired ossification in mice lacking the transcription factor Sp3.

Mechanisms of development - 1 Aug 2001

Göllner H, Dani C, Phillips B, Philipsen S, Suske G

Abstract excerpt

Sp3 is a ubiquitously expressed member of the Sp family of transcription factors. Recently, the mouse Sp3 gene has been disrupted by homologous recombination. Sp3 null mice die immediately after birth due to respiratory failure. In addition, these mice show a pronounced defect in late tooth formation. Here we show that Sp3 is also required for proper skeletal ossification. Both endochondral and intramembranous...

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Source

Identifiers

PMID: 11472836
DOI: 10.1016/s0925-4773(01)00420-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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