Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives.

doi:10.1016/j.ydbio.2005.02.002

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Article

Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives.

Developmental biology - 15 Apr 2005

Engleka Kurt A, Gitler Aaron D, Zhang Maozhen, Zhou Diane D, High Frances A, Epstein Jonathan A

Abstract excerpt

Pax3 is a transcription factor expressed in the dorsal neural tube and somite of the developing embryo. It plays critical roles in pre-migratory neural crest cells and in myogenic precursors of skeletal muscle. Pax3-deficient Splotch embryos display neural tube and neural crest defects and lack hypaxial muscles. We have created a new allele of Splotch by replacing the first coding exon with a gene encoding Cre...

Topics

Alleles
Animals
Cell Movement
DNA-Binding Proteins
Embryo, Mammalian
Exons
Genetic Techniques
Genotype
Heterozygote
Homozygote
Immunoblotting
Immunohistochemistry
In Situ Hybridization
Mice

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Models, Genetic

Muscle, Skeletal

Neurons

Source

Open in PubMed

Identifiers

PMID: 15882581
DOI: 10.1016/j.ydbio.2005.02.002

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