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Article

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells.

Molecular cancer therapeutics - 1 May 2008

Alfano Randall W, Leppla Stephen H, Liu Shihui, Bugge Thomas H, Herlyn Meenhard, Smalley Keiran S, Bromberg-White Jennifer L, Duesbery Nicholas S, Frankel Arthur E

Abstract excerpt

Anthrax lethal toxin (LeTx) shows potent mitogen-activated protein kinase pathway inhibition and apoptosis in melanoma cells that harbor the activating V600E B-RAF mutation. LeTx is composed of two proteins, protective antigen and lethal factor. Uptake of the toxin into cells is dependent on proteolytic activation of protective antigen by the ubiquitously expressed furin or furin-like proteases. To circumvent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18483309
DOI: 10.1158/1535-7163.MCT-08-0024
PMCID: PMC2757055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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