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Article

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature.

The Journal of biological chemistry - 4 Jan 2008

Liu Shihui, Wang Hailun, Currie Brooke M, Molinolo Alfredo, Leung Howard J, Moayeri Mahtab, Basile John R, Alfano Randall W, Gutkind J Silvio, Frankel Arthur E, Bugge Thomas H, Leppla Stephen H

Abstract excerpt

Anthrax lethal toxin (LT), a virulence factor secreted by Bacillus anthracis, is selectively toxic to human melanomas with the BRAF V600E activating mutation because of its proteolytic activities toward the mitogen-activated protein kinase kinases (MEKs). To develop LT variants with lower in vivo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17974567
DOI: 10.1074/jbc.M707419200
PMCID: PMC2394502

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17974567-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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