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Article

Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth.

Cancer research - 15 Oct 2007

Rogers Michael S, Christensen Kenneth A, Birsner Amy E, Short Sarah M, Wigelsworth Darran J, Collier R John, D'Amato Robert J

Abstract excerpt

Bacillus anthracis protective antigen (PA), the B subunit of the binary anthrax toxin, binds to the cellular receptors capillary morphogenesis gene 2 protein and tumor endothelial marker 8 with high affinity. Both receptors are expressed on endothelial cells during angiogenesis. We sought to determine whether one could inhibit angiogenesis by interfering with the binding of these receptors to their endogenous...

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PMID: 17942931
DOI: 10.1158/0008-5472.CAN-07-0829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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