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Article

Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009

Liu Shihui, Bugge Thomas H, Frankel Arthur E, Leppla Stephen H

Abstract excerpt

Anthrax toxin is a three-part toxin secreted by Bacillus anthracis, consisting of protective antigen (PrAg), edema factor (EF), and lethal factor (LF). To intoxicate host mammalian cells, PrAg, the cell-binding moiety of the toxin, binds to cells and is then proteolytically activated by furin on the cell surface, resulting in the active heptameric form of PrAg. This heptamer serves as a protein-conducting channel...

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Identifiers

PMID: 19377974
DOI: 10.1007/978-1-60327-003-8_10
PMCID: PMC3393601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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