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Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.

Cancer research - 1 Nov 2000

Liu S, Netzel-Arnett S, Birkedal-Hansen H, Leppla S H

Abstract excerpt

Matrix metalloproteinases (MMPs) are overexpressed in a variety of tumor tissues and cell lines, and their expression is highly correlated to tumor invasion and metastasis. To exploit these characteristics in the design of tumor cell-selective cytotoxins, we constructed two mutated anthrax toxin...

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PMID: 11085528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11085528-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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