Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.

Cancer research - 1 Nov 2000

Liu S, Netzel-Arnett S, Birkedal-Hansen H, Leppla S H

Abstract excerpt

Matrix metalloproteinases (MMPs) are overexpressed in a variety of tumor tissues and cell lines, and their expression is highly correlated to tumor invasion and metastasis. To exploit these characteristics in the design of tumor cell-selective cytotoxins, we constructed two mutated anthrax toxin protective antigen (PA) proteins in which the furin protease cleavage site is replaced by sequences selectively cleaved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Coculture Techniques
Share to Fibrosarcoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Matrix Metalloproteinase 2

Share to Matrix Metalloproteinase 9

Share to Matrix Metalloproteinases

Share to Metalloendopeptidases

Share to Vero Cells

Source

Identifiers

PMID: 11085528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.PMID 11085528Read ↗

Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin.Semantic proximity Read ↗

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature.Semantic proximity Read ↗

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells.Semantic proximity Read ↗

Tumor endothelium marker-8 based decoys exhibit superiority over capillary morphogenesis protein-2 based decoys as anthrax toxin inhibitors.Semantic proximity Read ↗

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors.Semantic proximity Read ↗

Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin.Semantic proximity Read ↗

Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.Semantic proximity Read ↗

Direct imaging of anthrax intoxication in animals reveals shared and individual functions of CMG-2 and TEM-8 in cellular toxin entrySemantic proximity Read ↗

Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth.Semantic proximity Read ↗

Immunotoxins with decreased immunogenicity and improved activity.Semantic proximity Read ↗

Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain.Semantic proximity Read ↗

A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.