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Article

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue.

The EMBO journal - 4 Jun 2008

Qi Jingzong, Gong Jingyi, Zhao Tongjin, Zhao Jie, Lam Penny, Ye Jing, Li John Zhong, Wu Jiawei, Zhou Hai-Meng, Li Peng

Abstract excerpt

We previously showed that Cidea(-/-) mice are resistant to diet-induced obesity through the upregulation of energy expenditure. The AMP-activated protein kinase (AMPK), consisting of catalytic alpha subunit and regulatory subunits beta and gamma, has a pivotal function in energy homoeostasis. We show here that AMPK protein levels and enzymatic activity were significantly increased in the brown adipose tissue of...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18480843
DOI: 10.1038/emboj.2008.92
PMCID: PMC2426729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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