Article

M1-linked Ubiquitination by LUBAC Regulates AMPK Activity and the Response to Energetic Stress

2024-11-10

Abstract excerpt

<h4>Summary</h4> Methionine-1 (M1)-linked ubiquitin chains, assembled by the ubiquitin ligase LUBAC and cleaved by the deubiquitinase OTULIN, are critical regulators of inflammation and immune homeostasis. Genetic loss of either LUBAC or OTULIN causes autoinflammatory syndromes, which are associated with defects in glycogen and lipid metabolism. However, how LUBAC and OTULIN regulate metabolic signalling remains...

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Literature Corpus work: 8cc53124-a207-5d18-9559-f7bada43688e
DOI: 10.1101/2024.11.08.622598

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