Article
Invariant chain association with MHC class I: preference for HLA class I/beta 2-microglobulin heterodimers, specificity, and influence of the MHC peptide-binding groove.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1996
Vigna J L, Smith K D, Lutz C T
Abstract excerpt
MHC class I molecules require the assembly of heavy chain with beta2-microglobulin (beta 2m) and peptide in order to present Ag on the cell surface. Endoplasmic reticulum resident proteins associate with class I molecules and aid assembly. Free class I heavy chains associate with calnexin, which...
Topics
- Antigens, CD
- Antigens, Differentiation, B-Lymphocyte
- HLA Antigens
- HLA-B7 Antigen
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Mutation
- Peptides
- Protein Binding
- Protein Conformation
- Protein Folding
- Transfection
- Tumor Cells, Cultured
- beta 2-Microglobulin