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Article

LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens.

Immunology - 1 Nov 2010

Crotzer Victoria L, Glosson Nicole, Zhou Delu, Nishino Ichizo, Blum Janice S

Abstract excerpt

Major histocompatibility complex (MHC) class II molecules present antigenic peptides derived from engulfed exogenous proteins to CD4(+) T cells. Exogenous antigens are processed in mature endosomes and lysosomes where acidic proteases reside and peptide-binding to class II alleles is favoured. Hence, maintenance of the microenvironment within these organelles is probably central to efficient MHC class II-mediated...

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Share to Antigen Presentation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20518820
DOI: 10.1111/j.1365-2567.2010.03309.x
PMCID: PMC2996552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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