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Article

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990

Valiquette M, Bonin H, Hnatowich M, Caron M G, Lefkowitz R J, Bouvier M

Abstract excerpt

Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the receptor away from the cell surface as well as a down-regulation of the total number of cellular receptors are believed to contribute to this agonist-mediated regulation of receptor number. However, the molecular mechanisms underlying these phenomena...

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Identifiers

PMID: 2164220
DOI: 10.1073/pnas.87.13.5089
PMCID: PMC54267

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Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.PMID 2164220Read ↗

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