Article
Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Valiquette M, Bonin H, Hnatowich M, Caron M G, Lefkowitz R J, Bouvier M
Abstract excerpt
Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the receptor away from the cell surface as well as a down-regulation of the total number of cellular receptors are believed to contribut...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Cell Membrane
- Colforsin
- Down-Regulation
- Humans
- Isoproterenol
- Kinetics
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Receptors, Adrenergic, beta
- Restriction Mapping
- Transfection