Article
Activation of gene expression by triplex-directed psoralen crosslinks.
Gene - 7 Jan 2004
Song Jie, Intody Zsofia, Li Mei, Wilson John H
Abstract excerpt
Psoralen-conjugated triplex-forming oligonucleotides (pso-TFOs) can target photochemical adducts to specific DNA sequences. Here, we have used pso-TFOs to activate gene expression on a plasmid. We designed a pso-TFO adapter, consisting of a single-stranded TFO for targeting DNA, linked to a doubl...
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