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Article

[Triple helix: a new promise for gene therapy].

Orvosi hetilap - 20 Apr 2003

Intödy Zsófia, Perkins Brian D, Wilson John H

Abstract excerpt

AIM: This publication focuses on the inhibition of gene expression by triplex-forming oligonucleotides, which is a promising approach to the treatment of dominant genetic diseases. The most common cause for autosomal dominant retinitis pigmentosa is a mutation in the rhodopsin gene. METHODS: Two psoralen-linked triplex-forming oligonucleotides were used to inhibit the expression from a plasmid carrying the...

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Identifiers

PMID: 12778626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Triple helix: a new promise for gene therapy].PMID 12778626Read ↗

Blocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinking.Semantic proximity Read ↗

Activation of gene expression by triplex-directed psoralen crosslinks.Semantic proximity Read ↗

Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides.Semantic proximity Read ↗

Gene therapy in animal models of autosomal dominant retinitis pigmentosa.Semantic proximity Read ↗

Recombination induced by triple-helix-targeted DNA damage in mammalian cells.Semantic proximity Read ↗

Activation of human gamma-globin gene expression via triplex-forming oligonucleotide (TFO)-directed mutations in the gamma-globin gene 5' flanking region.Semantic proximity Read ↗

Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids.Semantic proximity Read ↗

Functional correction of episomal mutations with short DNA fragments and RNA-DNA oligonucleotides.Semantic proximity Read ↗

Repair of rhodopsin mRNA by spliceosome-mediated RNA trans-splicing: a new approach for autosomal dominant retinitis pigmentosa.Semantic proximity Read ↗

Targeted correction of a thalassemia-associated beta-globin mutation induced by pseudo-complementary peptide nucleic acids.Semantic proximity Read ↗

Combinatorial library of biodegradable polyesters enables delivery of plasmid DNA to polarized human RPE monolayers for retinal gene therapySemantic proximity Read ↗

Unambiguous demonstration of triple-helix-directed gene modification.Semantic proximity Read ↗

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