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Oxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022.

Mutation research - 13 Sept 1999

Will O, Gocke E, Eckert I, Schulz I, Pflaum M, Mahler H C, Epe B

Abstract excerpt

The oxidative DNA damage induced by the polar photosensitizer Ro19-8022 in the presence of light was studied and correlated with the associated mutagenicity. Both in isolated DNA and AS52 Chinese hamster ovary cells, photoexcited Ro19-8022 gave rise to a DNA damage profile that was similar to that caused by singlet oxygen: base modifications sensitive to the repair endonuclease Fpg protein, which according to...

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PMID: 10526220
DOI: 10.1016/s0921-8777(99)00039-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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