Article
Peptide nucleic acid-mediated recombination for targeted genomic repair and modification.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Schleifman Erica B, Glazer Peter M
Abstract excerpt
The ability to directly manipulate the human genome to correct a disease-related mutation, introduce a sequence change that would lead to site-specific gene knockout, or increase gene expression is a very powerful tool with tremendous clinical value. Triplex formation by synthetic DNA-binding molecules such as peptide nucleic acids (PNAs) has been studied for over 20 years and much of the work in the last 10...
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