Article
Blocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinking.
Nucleic acids research - 1 Nov 2000
Intody Z, Perkins B D, Wilson J H, Wensel T G
Abstract excerpt
To explore the ability of triplex-forming oligodeoxyribonucleotides (TFOs) to inhibit genes responsible for dominant genetic disorders, we used two TFOs to block expression of the human rhodopsin gene, which encodes a G protein-coupled receptor involved in the blinding disorder autosomal dominant retinitis pigmentosa. Psoralen-modified TFOs and UVA irradiation were used to form photoadducts at two target sites in...
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