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Article

Functional analysis of the four DNA binding domains of replication protein A. The role of RPA2 in ssDNA binding.

The Journal of biological chemistry - 28 Sept 2001

Bastin-Shanower S A, Brill S J

Abstract excerpt

Replication Protein A (RPA), the heterotrimeric single-stranded DNA (ssDNA)-binding protein of eukaryotes, contains four ssDNA binding domains (DBDs) within its two largest subunits, RPA1 and RPA2. We analyzed the contribution of the four DBDs to ssDNA binding affinity by assaying recombinant yeast RPA in which a single DBD (A, B, C, or D) was inactive. Inactivation was accomplished by mutating the two conserved...

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Identifiers

PMID: 11479296
DOI: 10.1074/jbc.M104386200
PMCID: PMC2796477

Genes

RPA1
RPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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